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Endocrine Abstracts

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ea0029p1157 | Nuclear receptors and Signal transduction | ICEECE2012

Estrogen priming is critical for effective progesterone receptor engagement with DNA in breast cancer cells: ChIP sequencing and microarray studies

Swinstead E. , Need E. , Grover P. , Smith E. , Buchanan G.

One in 11 women develop breast cancer before the age of 75, and mortality is significant. Estrogens and progesterone (PROG) are mediators of breast cancer aetiology and progression, and are targets for both diagnostics and therapy. The actions of estrogens via estrogen receptor alpha (ERĪ±) have been extensively studied, but the genomic actions of PROG via the progesterone receptor (PGR) are still not fully understood. This study investigates the genomic actions of PGR in ...
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Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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